IL-17 was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. The cytokine exhibits a high degree of amino acid identity with HVS13，an open reading frame from a T lymphotropic Herpesvirus saimiri and with murine CTLA8. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 （ICAM-1） in human fibroblasts. IL-17 is a disulfide-linked homodimer of two 31.0 kDa subunits，each containing 136 amino acid residues.
应用类型
Western blot analysis （0.5-1 ug/ml） and ELISA （2-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
E. coli expressed human IL-17
来源宿主
兔
反应性
经检测验证，可与人种属来源的IL-17蛋白发生免疫反应.
保存建议
提供的IL-17抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 10 mM EDTA和0.02% thymersal.的PBS （pH 7.2）缓冲液中.请将该IL-17抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
