Glial cell line-derived neurotrophic factor （GDNF） has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated，disulfide-bonded homodimer. It promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings，it has been suggested that GDNF may play a role in the treatment of Parkinson’s disease，which is marked by progressive degeneration of midbrain dopaminergic neurons.
应用类型
Western blotting （0.5-4 ug/ml）. Based on researcher’s feedback， the antibody also works in immunoprecipitation （10-20 ug/ml）， and Immunohistochemistry （10-20 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes GDNF of human， mouse， and rat origins. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 195 of mouse GDNF
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的GDNF蛋白发生免疫反应.
保存建议
提供的GDNF抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该GDNF抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
