Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases，such as ASK-1 and RIP，are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase （death-associated protein kinase），which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family，which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.
应用类型
Immunocytochemistry: 10 ug/ml； Western Blot: 0.5 – 1 ug/ml； ELISA. However， the optimal conditions should be determined individually.
免疫原
Peptide corresponding to amino acids near the center of human ZIP Kinase.
