Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant human Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
序列
重组人内皮抑素蛋白产品，又称Collagen alpha-1(XVIII) chain, Endostatin-XV, Related to endostatin, Restin.其对应NCBI基因号为80781，对应Accession号为P39060.
来源宿主
提供的【Endostatin】重组人内皮抑素产品的来源为大肠杆菌重组表达.
溶解建议
重组人内皮抑素产品请按照说明书建议进行溶解操作：Reconstitute with sterile dH₂O to a concentration ≥ 1.0 mg/ml, aliquot and store at below –20°C. Avoid freeze-thaw cycles.
