The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystine knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
重组人前神经生长因子产品请按照说明书建议进行溶解操作：Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 ug/ml.). This can further be diluted to other aqueous buffers.
