SREBP （Sterol Regulatory Element Binding Protein） 1 and 2 are transcription factors th at regulates cholesterol homeostasis. SREBP proteins are attached to the endoplasmic reticulum and nuclear envelope. SREBP proteins undergo proteolytic cleavage in response to conditions of low cellular sterol. Upon activation of SREBP 1，a soluble NH2 cleavage fragment translocate to the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis.
应用类型
The antibody can be used for Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Blocking peptide （Cat.# 3961BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 318 of rat SREBP1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的SREBP1蛋白发生免疫反应
保存建议
提供的100 ug SREBP1抗体产品为无色溶液其浓度为0.5mg/ml溶解于包含有30%甘油， 0.5% BSA， 5 mM EDTA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该SREBP1抗体产品置于-20 °C冷冻保存，建议分装使用以避免反复冻融.
