Phosphatidylinositol 3-kinase （PI 3-kinase），is a phosphoinositide-specific protein kinase that plays a central role in mitogenic signal transduction leading to cellular regulation，cell growth and differentiation，and oncogenesis. PI 3-kinase associates with，and is activated by a wide range of tyrosine kinase receptors including EGF，PDGF，CSF-1，erbB-3 and insulin receptor，non-receptor protein-tyrosine kinases of the src family （e.g. pp60src），and crk and abl proto-oncogene products. PI 3-kinase is involved in signal transduction in terminally differentiated，activated cells like platelets and neutrophils.
应用类型
The antibody can be used for Western blot analysis （1-4 ug/ml）. However， the optimal conditions should be determined individually. Blocking peptide （Cat.# 3959BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 505 of mouse P13 kinase.
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的PI3 kinase蛋白发生免疫反应
保存建议
提供的100 ug PI3 kinase抗体产品为无色溶液其浓度为0.5mg/ml溶解于包含有30%甘油， 0.5% BSA， 5 mM EDTA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该PI3 kinase抗体产品置于-20 °C冷冻保存，建议分装使用以避免反复冻融.
