The histone methyltransferase KMT1A / SUV39H1 is the mammalian homologue of the Drosophila PEV modifier Su（var）3-9 protein. SUV39H1 contains the SET and chromo domains. In eukaryotic cells，SUV39H1 and the methyl-lysine binding protein HP1 interact to repress transcription at heterochromatic sites. SUV39H1 methylates histone H3 on lysine 9，which generates a binding site for HP1 proteins that plays a role in heterochromatin formation and gene silencing.
应用类型
Western blot analysis （1-4 ug/ml）. However， the optimal conditions should be determined individually. 3T3 cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 389 of mouse Histone Methyltransferase.
