The neurotransmitter/hormone adrenaline （epinephrine，adrenalin） plays a central role in the mammalian stress response，increasing heart rate，raising blood pressure，and increasing blood glucose levels. Adrenaline activates both alpha-adrenergic receptors and beta-adrenergic receptors. There are mainly three subtypes of beta adrenergic receptors known，beta1，beta2， and beta3. These receptors are expressed primarily in the heart，respiratory tissue，and adipose tissue. Beta3-receptors are abundant in brown adipocytes and play vital roles in lipolysis and thermoregulation. Beta adrenergic receptors are gaining much interest among researches in the studies of type-2 diabetes mellitus and obesity. It is also being considered as a therapeutic target for heart failure.
应用类型
Western blot analysis （1-4 ug/ml）. However， the optimal conditions should be determined individually. Rat kidney tissue lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 405 of rat Beta3-AR
来源宿主
兔
反应性
经检测验证，可与大鼠种属来源的Beta3-AR蛋白发生免疫反应.
保存建议
提供的Beta3-AR抗体产品为200 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该Beta3-AR抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
