The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes，including cytoskeletal reorganization，MAPK signaling，apoptotic signaling，etc. PAK 5 is known for promoting neurite outgrowth and thus predominantly expressed in the brain. PAK 5 contains CDC42/Rac1and has shown to bind CDC42 in the presence of GTP. PAK 5 also plays an important role in inhibiting apoptotic cascade throμgh BAD phosphorylation.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 90 of human PAK5/PAK7
