Transcription factor A mitochondria （TFAM） is an important activator of mitochondrial DNA transcription and replication. Studies in mice have shown that TFAM is required to regulate the mitochondrial genome copy number and is important for embryonic development. TFAM has been associated with mitochondrial disorder which includes ocular myopathy and muscular wasting in humans. Kearns-Sayre syndrome was shown in mouse model when expression of the gene was eliminated by targeted disruption in heart and muscle cells.
应用类型
Western blotting （0.5-4ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 27 kDa band from rat kidney tissue lysate. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 225 of rat TFAM
来源宿主
兔
反应性
经检测验证，可与大鼠种属来源的TFAM蛋白发生免疫反应.
保存建议
提供的TFAM抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该TFAM抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
