Mitofusin 2 （Mfn 2） is mostly expressed in the heart and muscle tissues. It is a transmembrane protein that mediates mitochondria fusion and plays a central role in the maintenance of mitochondrial morphology. A GTPase domain is required for the function of Mitofusin proteins. Mutations in Mfn2 can lead to Charcot-Marie-Tooth disease，a common inherited disorder of the peripheral nervous system. Mfn2 may also be associated with obesity and/or apoptosis.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 68 kDa and 86 kDa bands from samples of human， mouse， rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 719 of human Mitofusin 2
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Mitofusin 2蛋白发生免疫反应.
保存建议
提供的Mitofusin 2抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Mitofusin 2抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
