Notch proteins are transmembrane receptor that regluate cell fate decisions. Four Notch homologs have been identified in mammals namely Notch 1，Notch 2，Notch 3 and Notch 4. The membrane ligand for Notch includes Jagged 1，Jagged 2 and Delta. Notch 1 is a 270 kDa transmembrane receptor that can be activated by Delta （Dl） ligand. Activation of Notch 1 will result in the proteolytic cleavage of Notch 1 into a 120 kDa length protein.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes a 120 kDa band from samples of human and mouse origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 1760 of mouse Notch1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Notch 1蛋白发生免疫反应.
保存建议
提供的Notch 1抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Notch 1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
