Mammalian EST sulfurylates the hydroxyl group of estrogenic steroids by transferring the sulfate from a cosubstrate adenosine 3’-phosphate-5’-phosphosulfate. Sulfurylated steroids do not bind to the estrogen receptor with high affinity and，therefore，are hormonally inactive. EST plays an important role in controlling the intracellular level of the receptor-active estrogens.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 195 of human Estrogen Sulfotransferase (EST)
