Vasodilator-stimulated phosphoprotein （VASP） belongs to the Ena/VASP family of adaptor proteins linking the cytoskeletal system to the signal transduction pathways. VASP functions in cytoskeletal organization，fibroblast migration，platelet activation and axon guidance. Three phosphorylation sites，Ser157，Ser239 and Thr278，have been identified. Ser157 is the major PKA phosphorylation site. Evidence suggests that VASP phosphorylation reduces its association with actin and has a negative effect on actin polymerization.
应用类型
Western blotting （0.5-4 ug/ml） and Immunohistochemistry. However， the optimal concentrations should be determined individually. The antibody recognizes 51 kDa phosphorylated VASP from samples of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic phospho peptide surrounding amino acid Ser157 of human VASP
