XAF-1 binds to XIAP，an inhibitor of caspases-3，-7，-9 and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP’s ability to inhibit cell death. XAF-1is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines. In contrast，XIAP levels have been shown to be high in a majority of cell lines.
应用类型
Western blot
免疫原
Synthetic peptide surrounding a.a. 306 of human XAF-1
