Bcl-B (also called Bcl2-L-10) is a novel anti-apoptotic member of the Bcl-2 family. Bcl-B is closest in amino acid sequence homology to Boo protein. It contains four Bcl-2 homologs. Bcl-B mRNA is widely expressed in adult human tissues. The Bcl-B protein binds to Bcl-2,Bcl-X(L),and Bax but not Bak. Bcl-B suppresses apoptosis induced by Bax,but not by Bak.
应用类型
Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate (Cat.# 2401-100) and rat kidney tissue lysate (Cat.# 2702-100) can be used as positive controls. The antibody recognizes 21 kDa Bcl-B from samples of human and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 10 of human Bcl-B
来源宿主
兔
反应性
经检测验证,可与人种属来源的Bcl-B 蛋白发生免疫反应.
保存建议
提供的Bcl-B 抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Bcl-B 抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.