BRCA1 is a breast cancer susceptibility gene that was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues，including breast and ovary，and encodes a predicted protein of 1863 amino acids. Like many other genes involved in familial cancer，BRCA1 appears to encode a tumor suppressor，a protein that acts as a negative regulator of tumor growth.
应用类型
Western blotting （1-2 ug/ml）. However， the optimal conditions should be determined individually. Other applications have not been tested yet. Detect human BRCA1 when phosphorylated at Ser1189.
免疫原
Phosphorylated synthetic peptide surrounding Serine 1189 of human BRCA1
