BIN-1 is a tumor suppressor protein that was identified in a genetic screen for proteins that interact with the MCY oncoprotein. BIN-1 inhibits the oncogenic activity of MYC，possibly through activating or facilitating apoptosis. BIN is a short-lived protein with a half-life of about 2 hours.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Other applications have not been tested. The antibody recognizes ~65 kDa band in samples from human， mouse and rat origins. A cleavage fragment （~45 kDa） can also be detected in apoptotic samples. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 578 of mouse BIN-1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Bin1蛋白发生免疫反应.
保存建议
提供的Bin1抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有0.1% BSA， 30%甘油和0.01%硫柳汞的PBS缓冲液中.请将该Bin1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
