FK506-binding protein 38 （FKBP38），a member of the immunophilin family，has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane （OMM）. Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion，resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Blocking peptide （Cat.# 3666BP-50） is available separately. The antibody recognizes a ~40 kDa band in samples from human， mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 344 of mouse FKBP38
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的FKBP38蛋白发生免疫反应.
保存建议
提供的FKBP38抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有0.1% BSA， 20%甘油和0.02%硫柳汞的PBS缓冲液中.请将该FKBP38抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
