Lectin-like oxidized low-density-lipoprotein receptor-1 （LOX-1），also known as oxidized low-density-lipoprotein receptor-1 （OLR-1），belongs to the C-type lectin family. LOX-1 binds and supports the internalization of multiple structurally unrelated macromolecules including oxidized LDL，advanced glycation end products （AGE），activated platelets，bacteria，apoptotic or aged cells，and heat shock proteins. Human LOX-1 gene encodes a 273 amino acid residues （aa） protein with a short N-terminal intracellular domain，a transmembrane domain，an extracellular stalk/neck region followed a C-type lectin-like domain （CTLD）. The expression of LOX-1 is induced by proinflammatory or proatherogenic stimuli，as well as by oxidized LDL itself and hemodynamic or oxidative stress. LOX-1-dependent oxidized LDL uptake also induces apoptosis by inducing the expression of the pro-apoptotic Bax and downregulation of the anti-apoptotic Bcl-2.
应用类型
Western blotting （0.5-4 ug/ml）， detecting the pro- （~50 kDa） and the mature （~30 kDa） forms of Lox-1 in samples from human， mouse and rat origins. Other applications have not been determined.
免疫原
Synthetic peptide near the N-terminus of human Lox-1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的LOX-1蛋白发生免疫反应.
保存建议
提供的LOX-1抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该LOX-1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
