FKBP12 is a member of the family of soluble receptors capable of binding to one of two major immunosuppressant agents. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes，cardiac and skeletal ryanodine receptors and the inositol 1，4，5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors，FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.
应用类型
Western blot （0.5-4 ug/ml）， immunoprecipitation （2-10 ug/ml） and Immunohistochemistry （2-10 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects 12 kDa FKBP12 protein in samples from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 10 of mouse FKBP12
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的FKBP12蛋白发生免疫反应.
保存建议
提供的FKBP12抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该FKBP12抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
