Human HDAC7 is composed of 912 amino acid residues. Althoμgh HDAC7 is localized mostly to the cell nucleus，it is also found in the cytoplasm，sμggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions，leading to the inhibition of gene transcription.
应用类型
Western blotting, Immunoprecipitation, Immunohistochemistry
免疫原
Synthetic peptide surrounding amino acid 921 of murine HDAC7
