HDAC1 is an active component of transcriptional corepressor complexes which can be recruited to specific promoter regions via transcriptional factors. HDAC1 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions，which leads to the inhibition of gene transcription.
应用类型
Western blotting （0.5-4 ug/ml）， Immunoprecipitation （10-20 ug/ml）， and Immunohistochemistry （10-20 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects the 62 kDa histone deacetylase 1. It does not cross-react with other HDAC proteins including HDAC2， 3， 4， 5， 6， 7， and 8.
免疫原
Synthetic peptide corresponding to the C-terminus of human HDAC1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的HDAC1蛋白发生免疫反应.
保存建议
提供的HDAC1抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该HDAC1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
