Apoptosis plays an important role in many cellular processes. Dio-1 （Death Inducer-O bliterator-1），a putative transcription factor，has been indicated to function in the onset of apoptosis. Dio-1 expression is upregulated when an apoptosis is detected. It translocates to the nucleus，and activates apoptosis during limb development. Dio-1 expression can be suppressed by caspase inhibitors and Bcl-2 expression.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Other applications have not been tested. The antibody recognizes the 62 kDa human and mouse Dio-1 in Western blot analysis. Jurkat cell lysate and mouse small intestine tissue lysate can be used as positive controls.
免疫原
Synthetic peptide near the N-terminus of mouse Dio-1
来源宿主
兔
反应性
经检测验证，可与人、小鼠种属来源的Dio-1蛋白发生免疫反应.
保存建议
提供的Dio-1抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Dio-1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
