PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four members of PLCs have been identified: PLCB，PLCg，PLCδ，and PLCe. In response to extracellular stimuli (e.g.，hormone，growth factors，neurotransmitters)，PLC hydrolizes phosphatidylinositol 4,5-biphosphate (PIP2) into two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLCg2 is engaged in antigen-dependent signaling in B-cells and collagen-dependent signaling in platelets.
应用类型
Western blot
免疫原
Synthetic peptide near the C-terminus of human PLCg2
