Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF，BLyS，TALL-1，THANK，and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors，TACI and BCMA，for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI，which bind to BAFF and April，BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases，and activate NF-kB and c-Jun N-terminal kinase.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 159 of mouse BAFF-R
