TRAFs （TNF receptor associated proteins） form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs （TRAF1-TRAF6）. Recently it has been shown that TRANCE/OPGL activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6. Mice deficient in TRAF6 are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function. Like TRAF2 and TRAF3，TRAF6 is also essential for perinatal and postnatal survival. These findings establish diverse and critical roles for TRAF6 in perinatal and postnatal survival，bone metabolism，LPS，and cytokine signaling.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 54 kDa TRAF6 in samples of human and mouse origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 436 of rat TRAF6
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的TRAF6蛋白 发生免疫反应.
保存建议
提供的TRAF6抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该TRAF6抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
