TRAFs （TNF receptor associated proteins） form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs （TRAF1-TRAF6）. TRAF3，originally named CRAF1，interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha （TNF-alpha） receptor-associated factors. TRAF3 binds only a single site，which contains the sequence PEQET，whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes 67 kDa TRAF3 of human， mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues around amino acid 107 of human TWEAK Receptor
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的TRAF3蛋白 发生免疫反应.
保存建议
提供的TRAF3抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该TRAF3抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
