Proteinase inhibitor 9 (PI-9，also designated cytoplasmic antiproteinase 3，or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta，lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis，and is also an inhibitor of capase-1 and，to a smaller extent，caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B，particulary during target cell killing
应用类型
Western blot
免疫原
Synthetic peptide mapping to the N-terminus of human PI-9
