The matrix metalloproteinases （MMP） are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide （LPS） or staphylococcal enterotoxin B （SEB）. MMP catalysis requires both calcium and zinc. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Blocking peptide （3531RBP-50） is available separately. The antibody recognizes the latent form （~68 kDa） and the active forms （~55 kDa and ~40 kDa） of MMP-11 from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 464 of mouse MMP-11
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的MMP-11蛋白 发生免疫反应.
保存建议
提供的MMP-11抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该MMP-11抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
