The matrix metalloproteinases （MMP） are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide （LPS） or staphylococcal enterotoxin B （SEB）. MMP catalysis requires both calcium and zinc. MMP-9 （also designated 92-kDa type IV collagenase or gelatinase B） has been shown to degrade bone collagens in concert with MMP-1 （also designated interstitial collagenase，fibroblast collagenase or collagenase-1），and cysteine proteases and may play a role in bone osteoclastic resorption.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes the full length （proenzyme， 92 kDa） and cleaved （active enzyme， 84 kDa） MMP-9 in samples from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 110 of human MMP-9
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的MMP-9蛋白 发生免疫反应.
保存建议
提供的MMP-9抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该MMP-9抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
