Glycogen synthase kinase 3 （GSK-3） is a serine/threonine protein kinase that has been implicated in the regulation of cell fate and in the Wnt signaling pathway. GSK-3 plays an important role in the PI3 kinase and Akt mediated cell survival pathways，and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3 and Ser9 of GSK-3B. GSK-3 has also been implicated in alzheimer’s disease. Six Tau protein isoforms have been identified，all of which are phosphorylated by GSK-3.
应用类型
Western blot analysis （1-2 ug/ml） and Immunohistochemistry （20-30 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects GSK-3 from human， mouse， & rat origin； non cross-reactive with GSK-3B.
