Mitochondrial NADH:ubiquinone oxidoreductase (complex I) catalyzes the first step in the electron transport chain，the oxidation of NADH to NAD+ coupled to proton translocation across the inner mitochondrial membrane. GRIM-19 is a component of the complex I and is a product of a cell death regulatory gene induced by interferon-b and retinoic acid. GRIM-19 has previously been detected in HeLa cells，predominantly in the nucleus，though punctate staining of the cytoplasm was also observed.
应用类型
Western blot
免疫原
Two synthetic peptides surrounding amino acid 19 and 55 of human GRIM-19
