Tau，a microtubule-binding protein which serves to stabilize microtubules in growing axons，is found to be hyperphosphorylated in paired helical filaments （PHF），the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified，all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.
应用类型
Western blotting （1:1000）， immunoprecipitation （1:500）； and Immunohistochemistry （1:100）. However， the optimal concentrations should be determined individually. The antibody recognizes 45-60 kDa human Tau-13. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to the N-terminus of the longest isoform of human Tau
来源宿主
小鼠
反应性
经检测验证，可与人种属来源的Tau-13蛋白发生免疫反应.
保存建议
提供的Tau-13抗体产品为100 ul 无色溶液，其浓度为N/A，溶解于包含有50%甘油， 1% BSA和0.02% 叠氮钠的PBS缓冲液中.请将该Tau-13抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
