Paxillin is one of the key components of integrin signaling. Tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization. Paxillin is phosphorylated by another focal adhesion component，focal adhesion kinase （FAK），at tyrosine 118. Phospho-Tyr118 may provide a docking site for recruitment of other signaling molecules to focal adhesions.
应用类型
Western blotting （1-2 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide corresponding to residues near the C-terminal sequence of human Paxillin
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Paxillin蛋白发生免疫反应.
保存建议
提供的Paxillin抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02% 叠氮钠的PBS缓冲液中.请将该Paxillin抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
