DNA mismatch repair genes have been found to be associated with hereditary nonpolyposis colorectal cancer （HNPCC）. Inherited mutations in the MSH2 were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic，gastric，breast，ovarian and small cell lung cancers also display microsatellite instability suggests that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
应用类型
Western blotting （1-4 ug/ml）， immunoprecipitation （15-25 ug/ml）， and Immunohistochemistry （15-25 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes the MSH2 of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide mapping to a region between 1-50 of MSH2
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的MSH2蛋白 发生免疫反应.
保存建议
提供的MSH2抗体 产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02% 叠氮钠的PBS缓冲液中.请将该MSH2抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
