Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups，CXCR and CCR，based on the 2 major classes of chemokines. One of the CCR receptors，CCR3 (eotaxin receptor)，is expressed on eosinophils and certain T cell population respond to a variety of CC chemokines apart from eotaxin，including RANTES，monocyte chemotactic protein (MCP)-2，MCP-3，and MCP-4. CCR3 facilitated infection by a more restricted subset of primary viruses，and binding of the CCR3 ligand，eotaxin，and inhibited infection by these isolates.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 332 of rat CCR3
