Calpains are cytosolic，calcium-dependent，cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpain-1 and 2 consist of a common small subunit and a large variable subunit. Domains in the large subunit include the amino terminal domain I，the proteinase domain II，domain III，and the EF-hand domain IV. Type I calpain requires micromolar amounts of calcium，while type II calpain requires millimolar amounts of calcium.
应用类型
Western blot
免疫原
Synthetic peptide mapping to the C-terminus of the domain III of human Calpain 2 large subunit
