The MBD family of proteins includes MeCP2，MBD1，MBD2，MBD3 and MBD4. MBD1 (methyl-CpG binding domain protein 1) binds to methylated CpG sites and represses gene transcription. MBD1 is recruited to both methylated and non-methylated CpGs by separate domains: the CXXC domain targets the protein to non-methylated CpGs whereas the MBD domain targets the protein to methylated CpG. MBD1 may also interact with histone methyltransferase SETDB1 to repress transcription.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 594 of human MBD1
