Caspase-8，a member of the caspase-family of proteases，plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases，such as caspase-3，-6，-7 and a death agonist member of the Bcl-2/Bcl-xL family，Bid，leading to apoptosis.
应用类型
Western blot
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 392 of mouse caspase-8
