Silent information regulator （Sir2）-like family deacetylases （also known as sirtuins） are highly conserved proteins and have important roles in the regulation of metabolism，inflammation，cellular survival growth and differentiation. Sirtuins，including SIRT1-7，are human homologs of yeast Sir2p. Sirtuins are NAD-dependent protein ADP-ribosyl transferase which catalyzes the transfer of ADP-ribosyl groups onto target proteins，including mitochondrial GLUD1. SIRT4 localizes to mitochondria，inhibits glutamate dehydrogenase （GLUD1），and may involve in the regulation of insulin secretion.
应用类型
Western Blot analysis （1-4 ug/ml）. However， the optimal concentrations should be determined individually. Blocking peptide （Cat.# 3224BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 72 of rat SIRT4
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的SIRT4蛋白发生免疫反应
保存建议
提供的100 ug SIRT4抗体产品为无色溶液其浓度为0.5 mg/ml溶解于包含有30%甘油， 0.5% BSA， 5 mM EDTA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该SIRT4抗体产品置于-20 °C冷冻保存，建议分装使用以避免反复冻融.
