Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis （IAPs）. These proteins contain a BIR （baculovirus IAP repeat） domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and –7. For example，XIAP，cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9，thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors，they may inhibit apoptosis by additional mechanisms.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 510 of human cIAP-2
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的cIAP-2/HIAP-1蛋白发生免疫反应.
保存建议
提供的cIAP-2/HIAP-1抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该cIAP-2/HIAP-1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
