STATs （signal transducers and activators of transcription） are a family of cytoplamic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signalling peptides including cytokines，interferons，and growth factors. After phosphorylation by JAK tyrosine kinases，STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs （Stat1，Stat2，Stat3，Stat4，Stat5a，Stat5b，and Stat6）. Stat1，Stat3，Stat5a and Stat5b have wide activation profiles. Stat1 is activated by many different ligands including IFN family （IFN-a，IFN-b，IFN-r，and IL-10），gp130 family （IL-6，IL-11，LIF，CNTF，and G-CSF-1），and receptor tyrosine kinases （EGF，PDGF，and CSF-1）. Stat1 has two forms，the 91 kDa STAT1 and the 84 kDa STAT1B，which are coded by the same gene with splicing variant.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes both alpha （91 kDa） and beta （84 kDa） subunits of STAT1 in samples from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 672 of rat Stat1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Stat1蛋白 发生免疫反应.
保存建议
提供的Stat1抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Stat1抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
