Insulin receptor substrates （IRS） subtypes are responsible for several insulin related activities，such as glucose homeostasis，cell growth，cell transformation，apoptosis and insulin signal transduction. The balance between Ser/Thr phosphorylation of IRS has been demonstrated to be an important regulator of insulin signaling. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer，Wilm’s tumors，and adrenal cortical carcinomas. Does not recognize IRS peptide NOT phosphorylated at Ser616 and will not recognize IRS peptide phosphorylated at Tyr183. Also does not react with riboflavin carrier protein which is known to have multiple phosphate groups.
应用类型
The antibody can be used for indirect ELISA and WB.
免疫原
Synthetic peptide phosphorylated at Ser 616 site
来源宿主
小鼠
反应性
经检测验证，可与人种属来源的Phospho-IRS （Ser616）蛋白发生免疫反应.
保存建议
提供的Phospho-IRS （Ser616）抗体产品为100 ug 无色溶液，其浓度为1.0 mg/ml，溶解于包含有0.05% （W/V） 叠氮钠的PBS缓冲液中.请将该Phospho-IRS （Ser616）抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
