CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L)，a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation，antibody class switching，modulation of apoptosis in the germinal center throμgh interaction with T cells expressing CD40L，and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells，CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6，a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.
应用类型
Western blot
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 261 of human CD40
