Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRa-2 is a member of the GDNF receptor family. It is a glycosylphosphatidyl-inositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NRTN compared to its other family member, GDNF family receptor alpha 1. http://www.ncbi.nlm.nih.gov/gene/2675
应用类型
ELISA, WB, IF
免疫原
human GFRa-2
来源宿主
鸡
反应性
Human GFRa-2, doesn’t cross-react with hGFRa-1, hGFRa-3, hGFRa-4
保存建议
Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use
