ITD-1（10毫克）产品是ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 uM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ = 0.4–0.8 uM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.
