Smo拮抗剂,SA10(2毫克)产品是SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 uM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 uM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.