- 中文名称
Leukotriene B4 Ethanolamide (500 ug)
- 英文名字
- LTB4-EA, Leukotriene B4 Ethanolamide, N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,1E,14Z-eicosatetraenamide
- 供应商
- Cayman
- 产品货号
- 20112-500
- 产品报价
- ￥25088/500 ug
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM. LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1.
- 产品描述
- A theoretical 5-LO metabolite of AEA; acts as a potent antagonist of the human BLT1 receptor (Ki = 1.22 nM)
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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